|
T8702 |
SKF-83566
|
|
Dopamine Receptor
,
5-HT Receptor
,
AChR
|
|
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
|
T0031L |
Ziprasidone hydrochloride
|
CP-88059 hydrochloride,CP-88059,Ziprasidone HCl |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
|
T7341 |
Diclofensine
|
Ro 8-4650 |
Dopamine Receptor
,
Monoamine Transporter
|
|
Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine. |
|
T1636 |
Paroxetine hydrochloride
|
Paroxetine HCl,BRL29060 hydrochloride,FG-7051,BRL29060A |
5-HT Receptor
,
Serotonin Transporter
,
GRK
,
AChR
,
Autophagy
|
|
Paroxetine hydrochloride (Paroxetine HCl) is a serotonin uptake inhibitor that is effective in the treatment of depression. |
|
T8708 |
Paroxetine
|
|
Serotonin Transporter
|
|
Paroxetine is a inhibitor of serotonin uptake that is effective in the treatment of depression. |
|
T0450 |
Fluoxetine
|
LY-110140 |
5-HT Receptor
,
Serotonin Transporter
,
MRP
,
Autophagy
|
|
Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity. |
|
T0204 |
Protriptyline hydrochloride
|
Protriptyline HCl |
5-HT Receptor
,
AChE
|
|
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride (Protriptyline HCl) blocks the re-uptake of norepineph... |
|
T0482 |
Sertraline hydrochloride
|
Sertraline HCl,CP-51974-1 HCl |
5-HT Receptor
,
Serotonin Transporter
|
|
Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression. |
|
T0450L |
Fluoxetine hydrochloride
|
Fluoxetine HCl,LY-110140,Lilly110140 |
5-HT Receptor
,
Serotonin Transporter
,
Autophagy
|
|
Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. |
|
T0255 |
Clomipramine hydrochloride
|
Clomipramine HCl,Anafranil |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
,
GST
|
|
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... |
|
T1471 |
Duloxetine hydrochloride
|
Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and i... |
|
T21013 |
Clomipramine
|
Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina |
5-HT Receptor
|
|
Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su... |
|
T1619 |
Trazodone hydrochloride
|
KB-831,Trazodone HCl,AF-1161 |
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressi... |
|
T1568 |
Amoxapine
|
CL-67772 |
GlyT
|
|
Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopa... |
|
T0991 |
Desipramine hydrochloride
|
NSC-114901,Desmethylimipramine,JB-8181,EX-4355,Norimipramine,G-35020 |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Adrenergic Receptor
|
|
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-upt... |
|
Fr13587 |
7-Chloro-4-(piperazin-1-yl)quinoline
|
|
|
|
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles. 7-Chloro-4-(piperazin-1-yl)q... |
|
T41194 |
FFN 102 mesylate
|
|
Others
|
|
FFN 102 mesylate is a pH responsive fluorescent false neurotransmitter (FFN), a selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine... |
|
T26765 |
Beloxepin
|
ORG-4428,ADL6906,ADL-6906,ORG4428,ORG 4428,ADL 6906 |
|
|
Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake. |
|
T71463 |
MCN-5652W68 perchlorate
|
|
|
|
MCN-5652W68 perchlorate is a serotonin uptake inhibitor. |
|
T27589 |
Ifoxetine sulfate
|
CGP-15210G,CGP15210G,CGP 15210G |
|
|
Ifoxetine sulfate, a 5-HT uptake inhibitor with atypical effects on serotonin uptake, may exhibit a therapeutic and/or side-effect profile which differs from that of classical 5-HT uptake inhibitors. |
|
T27156 |
Dexnafenodone Hydrochloride
|
LU43706,LU 43706,Dexnafenodone HCl,LU-43706 |
|
|
Dexnafenodone Hydrochloride is an adrenergic receptor antagonist and serotonin uptake inhibitor. |
|
T68949 |
Chlorocitalopram hydrobromide
|
|
|
|
Chlorocitalopram hydrobromide is an internal standard of Citalopram -- an inhibitor of serotonin (5-HT) uptake. |
|
T68210 |
MCN-5652 perchlorate
|
|
|
|
MCN-5652 perchlorate is a serotonin uptake inhibitor. |
|
T70261 |
Amitriptyline Embonate
|
|
|
|
Amitriptyline Embonate is an inhibitor of the re-uptake of norepinephrine and serotonin, thereby inhibiting N-methyl-D-aspartate (NMDA) receptors. |
|
T25248 |
Cianopramine
|
Ro 112465,Ro-112465,Ro112465 |
|
|
Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals. |
|
T29216 |
Zimelidine
|
A23140,A 23140,A-23140 |
|
|
Zimelidine is a serotonin uptake inhibitor formerly used for depression, but was withdrawn worldwide because of the risk of Gullain-Barre syndrome associated with its use. |
|
T26184 |
Seproxetine HCl
|
(S)-Norfluoxetine hydrochloride,Seproxetine hydrochloride,(S)-Desmethylfluoxetine Hydrochloride |
|
|
Seproxetine HCl, a more active enantiomer of N-desmethyl metabolite fluoxetine, works by selectively inhibiting the serotonin uptake carrier. |
|
T69002 |
Zimeldine hydrochloride hydrate
|
|
|
|
Zimeldine hydrochloride hydrate is a serotonin uptake inhibitor that was formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of Guillain-Barre Syndrome associated with its use. |
|
T69943 |
Citalopram oxalate
|
|
|
|
Citalopram oxalate is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients wh... |
|
T27689 |
JNJ-7925476 HCl
|
JNJ-7925476,JNJ7925476,JNJ 7925476 |
|
|
JNJ-7925476 HCl is a triple monoamine uptake inhibitor. JNJ-7925476 Salt blocks the dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter (SERT) in the central nervous system. The ED(50) ... |
|
T35920 |
N-methyl Paroxetine
|
|
|
|
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptak... |
|
T28349 |
PD-89211
|
PD89211 |
|
|
PD 89211 is a selective dopamine D4 receptor antagonist with high selectivity for the DA D4.2 receptor (> 800-fold) as compared to other hDA receptor subtypes, rat brain serotonin, and adrenergic receptors. In vitro, PD ... |
|
T37212 |
5-hydroxy-Nω-methyl Tryptamine (oxalate)
|
|
|
|
5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants. It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay). 5-hydroxy-Nω-me... |
|
TMIH-0205 |
Duloxetine-d3 HCl
|
|
|
|
Duloxetine-d3 HCl is a deuterated compound of Duloxetine HCl. Duloxetine HCl has a CAS number of 136434-34-9. Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTON... |
|
T71302 |
Norfluoxetine-d5 HCl
|
|
|
|
Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine b... |
|
TMIH-0582 |
Trazodone-d8 hydrochloride
|
|
|
|
Trazodone-d8 hydrochloride is a deuterated compound of Trazodone hydrochloride. Trazodone hydrochloride has a CAS number of 25332-39-2. Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepre... |
|
T78126 |
Dothiepin
|
Dosulepin,Dothep |
Histamine Receptor
|
|
Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. ... |
|
TMIH-0184 |
Desipramine-d3 HCl
|
|
|
|
Desipramine-d3 HCl is a deuterated compound of Desipramine HCl. Desipramine HCl has a CAS number of 58-28-6. Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of d... |
